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. 1976 Dec;3(6):281-5.
doi: 10.1002/bms.1200030606.

Determined of bufuralol and its metabolites in plasma by mass fragmentography and by gas chromatography with electron capture detection

R J Francis, P B East, S J McLaren, J Larman

Determined of bufuralol and its metabolites in plasma by mass fragmentography and by gas chromatography with electron capture detection

R J Francis et al. Biomed Mass Spectrom. 1976 Dec.

Abstract

A sensitive method for the simulataneous determination of bufuralol and its pharmacologically active metabolites in huamn plasma is described. The O-timethylsilyl,N-trifluoroacetyl derivatives are assayed by mass fragmentography. Sensitivity is 1 ng 76(-1) plasma for bufaralol and about 250 pg ml(-1) for the metabolites. An alternative procedure which uses gas chromatography with electron capture detection is also described. The sensitivity of this is about 10 ng ml(-1) plasma for all drug-related components.

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