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. 1976 Nov 27;2(6047):1284-7.
doi: 10.1136/bmj.2.6047.1284.

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods

F A Drasar, W Farrell, J Maskell, J D Williams

Tobramycin, amikacin, sissomicin, and gentamicin resistant Gram-negative rods

F A Drasar et al. Br Med J. .

Abstract

Sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant Gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. Amikacin was the aminoglycoside most active against gentamicin-resistant organisms, Pseudomonas aeruginosa, klebsiella spp, Escherichia coli, Proteus spp, Providencia spp, and Citrobacter spp being particularly susceptible. Most of the gentamicin-resistant organisms were isolated from the urine of patients undergoing surgery. Gentamicin was the most active antibiotic against gentamicin-sensitive E coli, Proteus mirabilis, and Serratia spp. Pseudomonas aeruginosa and other Pseudomonas spp were most susceptible to tobramycin.

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