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. 1976 Oct 21;450(1):69-77.
doi: 10.1016/0005-2760(76)90299-x.

Secretion of lecithin: cholesterol acyltransferase from isolated rat hepatocytes

G Nordby, T Berg, M Nilsson, K R Norum

Secretion of lecithin: cholesterol acyltransferase from isolated rat hepatocytes

G Nordby et al. Biochim Biophys Acta. .

Abstract

1. Lecithin:cholesterol acyltransferase is secreted from isolated rat heptocytes. 2. The secretion is stimulated when serum is added to the incubation medium. 3. Optimal conditions for secretion are: 5-10(6) hepatocytes per ml, 5 h incubation, pH 7.3-7.4 and 25% serum in the incubation medium. 4. Concomitantly with the secretion of lecithin:cholesterol acyltransferase there is a secretion of unesterified cholesterol and triacylglycerol. 5. Colchicine or cycloheximide in the incubation medium inhibits secretion of lecithin:cholesterol acyltransferase.

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