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Review
. 1999 Jan 28;9(2):R62-5.
doi: 10.1016/s0960-9822(99)80012-8.

Cancer genetics: tumor suppressor meets oncogene

E R Fearon  1 , C V Dang
Affiliations
Free article
Review

Cancer genetics: tumor suppressor meets oncogene

E R Fearon et al. Curr Biol. .
Free article

Abstract

The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.

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