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Review
. 1999 Feb;3(1):11-5.
doi: 10.1016/s1367-5931(99)80003-9.

Dynamic kinetic resolution

M T Gihani  1 , J M Williams
Affiliations
Review

Dynamic kinetic resolution

M T Gihani et al. Curr Opin Chem Biol. 1999 Feb.

Abstract

The use of transition-metal-enzyme combinations to effect tandem in situ racemisation and resolutions has extended the scope of dynamic kinetic resolutions. This methodology has signalled a more proactive stance to the racemisation process, which has traditionally relied on more fortuitous approaches, namely the exploitation of labile substrates. The development and application of specific racemising enzymes such as mandelate racemase offers potential for future multienzyme dynamic kinetic resolutions.

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