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Comparative Study
. 1999 Feb;22(2):208-12.
doi: 10.1002/(sici)1097-4598(199902)22:2<208::aid-mus8>3.0.co;2-b.

Effects of training on exercise-induced muscle damage and interleukin 6 production

J L Croisier  1 , G Camus, I Venneman, G Deby-Dupont, A Juchmès-Ferir, M Lamy, J M Crielaard, C Deby, J Duchateau
Affiliations
Comparative Study

Effects of training on exercise-induced muscle damage and interleukin 6 production

J L Croisier et al. Muscle Nerve. 1999 Feb.

Abstract

To address the question of whether the increased plasma concentration of interleukin 6 (IL-6) following strenuous muscular work could be related to exercise-induced muscle damage, 5 moderately active male volunteers underwent two isokinetic exercise sessions in the eccentric mode, separated by a period of 3 weeks during which the subjects underwent five training sessions. Before training, exercise was followed by severe muscle pain (delayed-onset muscle soreness; DOMS), and by significant increases in plasma IL-6 level and serum myoglobin concentration (SMb) (P < 0.001). After training, postexercise DOMS and SMb values were significantly lower than those measured before training. There was no significant difference between plasma IL-6 levels measured at the same time points before and after training. We conclude that the hypothetical relationship between exercise-induced muscle damage and increased postexercise levels of circulating IL-6 is not substantiated by the present results.

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