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. 1999 Feb 5;96(3):389-92.
doi: 10.1016/s0092-8674(00)80551-6.

Histone octamer transfer by a chromatin-remodeling complex

Y Lorch  1 , M Zhang, R D Kornberg
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Free article

Histone octamer transfer by a chromatin-remodeling complex

Y Lorch et al. Cell. .
Free article

Abstract

RSC, an abundant, essential chromatin-remodeling complex related to SWI/SNF complex, catalyzes the transfer of a histone octamer from a nucleosome core particle to naked DNA. The newly formed octamer-DNA complex is identical with a nucleosome in all respects. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. The mechanism may entail formation of a duplex displacement loop on the nucleosome, facilitating the entry of exogeneous DNA and the release of the endogenous molecule.

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