Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Dec 1;144(6):1689-94.
doi: 10.1084/jem.144.6.1689.

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids

J Hamilton, J D Vassalli, E Reich

Macrophage plasminogen activator: induction by asbestos is blocked by anti-inflammatory steroids

J Hamilton et al. J Exp Med. .

Abstract

Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.

PubMed Disclaimer

References

    1. AMA Arch Intern Med. 1951 Dec;88(6):831-4 - PubMed
    1. Cell. 1976 Jun;8(2):271-81 - PubMed
    1. Proc R Soc Med. 1973 Apr;66(4):395-403 - PubMed
    1. Nature. 1974 Oct 4;251(5474):423-5 - PubMed
    1. J Exp Med. 1974 Oct 1;140(4):995-1010 - PubMed

Publication types