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. 1976 Oct;57(4):955-7.
doi: 10.1093/jnci/57.4.955.

Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine

D Dagani, M C Archer

Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine

D Dagani et al. J Natl Cancer Inst. 1976 Oct.

Abstract

The rates of N-demethylation of dimethylnitrosamine and dimethylnitrosamine-d6 by rat liver microsomes were studied by monitoring formaldehyde production. Deuterium isotope effects of 1.6 and 3.8 were found for the Michaelis constant and the maximum velocity, respectively.

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