Human T cell leukemia virus type-I and rheumatoid arthritis

Abstract

HTLV-I is a retrovirus known as an oncogenic virus for human. This virus, initially found as a causative agent for adult T cell leukemia, has been lately focused as a causative virus for several autoimmune disorders. Here we described the characteristics of polyarthritis in HTLV-I careers, which is indistinguishable from idiopathic rheumatoid arthritis (RA). The relationship between arthritis and this virus was clearly proved by epidimiological study. Moreover, we presented transactivating gene of this virus, tax, is responsible for proliferation of synovial cells. This was proved by Tax transgenic mice, which present chronic destructive arthritis resembling human RA. Other autoimmune disorders, such as Sjögren's syndrome and uveitis, are also reviewed.