Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Oct;295(1):41-4.
doi: 10.1007/BF00509770.

Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine

E Müller-Schweinitzer

Evidence for stimulation of 5-HT receptors in canine saphenous arteries by ergotamine

E Müller-Schweinitzer. Naunyn Schmiedebergs Arch Pharmacol. 1976 Oct.

Abstract

Changes in tension of spiral strips from dog saphenous arteries were monitored isometrically. Dose-response curves for noradrenaline, 5-HT and ergotamine were established without and after a 30 min incubation with phentolamine or pizotifen. Phentolamine was about 15 times more potent in antagonizing responses to noradrenaline (pA2 value=7.4) than those to 5-HT (pA2 value=6.2) but it was nearly equipotent in antagonizing responses to ergotamine (pA2 value=6.5) and those to 5-HT. Pizotifen was about 500 times less potent in antagonizing noradrenaline effects than 5-HT but again nearly equipotent when tested against ergotamine and 5-HT. It is suggested that in canine saphenous arteries the stimulant activity of ergotamine is mediated mainly through 5-HT receptors.

PubMed Disclaimer

References

    1. Blood Vessels. 1975;12(4):193-205 - PubMed
    1. Br J Pharmacol Chemother. 1959 Mar;14(1):48-58 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1976;292(2):113-8 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R68 - PubMed
    1. Br J Pharmacol Chemother. 1947 Sep;2(3):189-206 - PubMed