Combinatorial gene regulation by eukaryotic transcription factors

Abstract

Recent structure determinations of high order complexes of eukaryotic transcription factors bound to DNA have revealed that residues from their DNA-binding domains are involved in protein-protein interactions between distinct factors. Protein-protein interactions between transactivation domains and coactivators have also been characterized in a number of recently determined structures. These studies support the combinatorial mechanism of transcription regulation in eukaryotic cells and multicellular organisms.