doi: 10.1093/nar/3.12.3293.
Chromatin structure: a property of the higher structures of chromatin and in the time course of its formation during chromatin replication
- PMID: 1005118
- PMCID: PMC343174
- DOI: 10.1093/nar/3.12.3293
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Chromatin structure: a property of the higher structures of chromatin and in the time course of its formation during chromatin replication
Nucleic Acids Res.
1976 Dec.
Free PMC article
Abstract
The action of a number of enzymes and metals on one nuclear preparation were interpreted in terms of the existence of a fragile but highly DNAase-I resistant feature of chromatin superstructure. The generation of this DNAase-I resistance feature of chromatin was then followed during normal DNA synthesis in the regenerating rat liver by following the disappearance of a transitory DNAase-I susceptible state. This transitory, DNAase-I susceptible state appears to be extremely similar to the post-synthetic, DNAase-I susceptible state that has been described in He La32.
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