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. 1976 Dec 24;194(4272):1427-8.
doi: 10.1126/science.1006308.

HLA antigens and corticosteroid response

B Becker, D H Shin, P F Palmberg, S R Waltman

HLA antigens and corticosteroid response

B Becker et al. Science. .

Abstract

Compared with normal individuals, patients with primary open-angle glaucoma have increased prevalences of HLA-B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA-B12 antigen require significantly (P less than .02) lower concentrations of prednisolone to inhibit phytohemagglutinin-induced transformation.

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