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Review
. 1999 Feb;31(1):29-41.
doi: 10.1081/dmr-100101906.

Modulation of drug metabolism in infectious and inflammatory diseases

H Iber  1 , M B Sewer, T B Barclay, S R Mitchell, T Li, E T Morgan
Affiliations
Review

Modulation of drug metabolism in infectious and inflammatory diseases

H Iber et al. Drug Metab Rev. 1999 Feb.

Abstract

During inflammation, expression of various P450 genes is modulated differentially. Both the downregulation of some P450s and the induction of others may be the result of a complex interaction involving inflammatory cytokines, stress hormones, and metabolic perturbations. Our results suggest that NO is not an important mediator for the downregulation of CYP2C11 in rat liver.

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