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. 1999 Mar;6(2):279-81.
doi: 10.1128/CDLI.6.2.279-281.1999.

Restricted isotypic antibody reactivity to hepatitis C virus synthetic peptides in immunocompromised patients

M Devesa  1 , A de Saez, G León, F Sirit, C Cosson, H Bermúdez, F Liprandi, O Noya, F H Pujol
Affiliations

Restricted isotypic antibody reactivity to hepatitis C virus synthetic peptides in immunocompromised patients

M Devesa et al. Clin Diagn Lab Immunol. 1999 Mar.

Abstract

An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide.

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