doi: 10.1007/BF02816390.
Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics
Affiliations
- PMID: 10069013
- DOI: 10.1007/BF02816390
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Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics
Folia Microbiol (Praha).
1998.
Abstract
The interaction of type-I beta-lactamases from Enterobacter cloacae with diverse beta-lactam compounds was examined. The ability of penicillin and cefoxitin to induce beta-lactamase production in this strain was assessed. The effect of beta-lactamase inhibitors was measured on beta-lactamase extracts and on intact cells. E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropriate choice for therapy of infections caused by stably derepressed mutants of Enterobacter sp. producing type-I beta-lactamases.
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