Review
doi: 10.1016/s0959-437x(99)80016-1.
Ras caught in another affair: the exchange factors for Ral
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- PMID: 10072355
- DOI: 10.1016/s0959-437x(99)80016-1
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Review
Ras caught in another affair: the exchange factors for Ral
Curr Opin Genet Dev.
1999 Feb.
Abstract
The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.
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