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Review
. 1999 Feb;9(1):112-7.
doi: 10.1016/s0959-437x(99)80016-1.

Ras caught in another affair: the exchange factors for Ral

R M Wolthuis  1 , J L Bos
Affiliations
Review

Ras caught in another affair: the exchange factors for Ral

R M Wolthuis et al. Curr Opin Genet Dev. 1999 Feb.

Abstract

The Ral guanine nucleotide exchange factors are direct targets of Ras, providing a mechanism for Ral activation by extracellular signals. In addition, Ral can be activated by a Ras-independent pathway. Ral guanine nucleotide exchange factors contribute to cellular transformation induced by oncogenic Ras through an Erk-independent mechanism which may involve activation of transcription.

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