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. 1997 Mar;18(2):189-91.

[Hippocampal non-NMDA and GABA-A receptors in benzylpenicillin-induced epilepsy and electro-acupuncture antiepilepsy]

[Article in Chinese]
J Liu  1 , J S Cheng
Affiliations
  • PMID: 10072980
Free article

[Hippocampal non-NMDA and GABA-A receptors in benzylpenicillin-induced epilepsy and electro-acupuncture antiepilepsy]

[Article in Chinese]
J Liu et al. Zhongguo Yao Li Xue Bao. 1997 Mar.
Free article

Abstract

Aim: To study the effect of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and bicuculline (Bic) on benzyl-penicillin-induced-epilepsy (PIE) and electroacupuncture (EA) antiepilepsy in rats.

Methods: Epilepsy was elicited by intra-hippocampal microinjection of benzylpenicillin in rats. The analysis of electroencephalogram (EEG) and power spectrum was used to measure the extent of convulsion.

Results: EA or DNQX (1 microgram) showed partial inhibitory effect on PIE. EA + DNQX caused further inhibition of PIE, and Bic attenuated EA antiepileptic effect.

Conclusion: Antagonization of GABA-A receptor attenuated EA antiepileptic effect, and EA acted synergistically with the antagonists of non-N-methyl-D-aspartate (non-NMDA) receptors.

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