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. 1999 Mar 12;283(5408):1742-5.
doi: 10.1126/science.283.5408.1742.

Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila

C Merrill  1 , L Bayraktaroglu, A Kusano, B Ganetzky
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Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila

C Merrill et al. Science. .

Abstract

Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd locus is the key distorting gene responsible for this phenotype. A genomic fragment from the Sd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.

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  • Unmasking a cheating gene.
    Crow JF. Crow JF. Science. 1999 Mar 12;283(5408):1651-2. doi: 10.1126/science.283.5408.1651. Science. 1999. PMID: 10189318 No abstract available.

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