Review
doi: 10.1016/s0960-9822(99)80106-7.
Ion channels: structure of a molecular brake
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- PMID: 10074448
- DOI: 10.1016/s0960-9822(99)80106-7
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Review
Ion channels: structure of a molecular brake
Curr Biol.
.
Free article
Abstract
A combination of crystallographic and mutagenesis studies on the HERG K+ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino-terminal domain might act as a 'molecular brake' that slows down channel deactivation.
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