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Review
. 1999 Mar 11;9(5):R173-5.
doi: 10.1016/s0960-9822(99)80106-7.

Ion channels: structure of a molecular brake

M S Sansom  1
Affiliations
Free article
Review

Ion channels: structure of a molecular brake

M S Sansom. Curr Biol. .
Free article

Abstract

A combination of crystallographic and mutagenesis studies on the HERG K+ channel, a key determinant of cardiac excitability, has suggested how the protein's extramembraneous amino-terminal domain might act as a 'molecular brake' that slows down channel deactivation.

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