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Review
. 1999 Mar;6(3):R65-9.
doi: 10.1016/s1074-5521(99)89002-4.

How Taxol stabilises microtubule structure

L A Amos  1 , J Löwe
Affiliations
Review

How Taxol stabilises microtubule structure

L A Amos et al. Chem Biol. 1999 Mar.

Abstract

The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.

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