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. 1999 Jan;11(1):81-5.
doi: 10.1016/s0924-8579(98)00061-2.

Influence of fever on the pharmacokinetics of ciprofloxacin

B Beovic  1 , A Mrhar, R Karba, T Zupancic, I Grabnar, A Belic, M Marolt-Gomiscek
Affiliations

Influence of fever on the pharmacokinetics of ciprofloxacin

B Beovic et al. Int J Antimicrob Agents. 1999 Jan.

Abstract

The influence of fever on the pharmacokinetics of ciprofloxacin was investigated in seven patients with acute febrile diseases. Antibiotic serum concentrations were determined using high-performance liquid chromatograpy (HPLC). The analog computer and the Simulink software package were used to identify the pharmacokinetic model and Penoclin software package to obtain the secondary parameters. During fever, higher maximum serum concentrations (Cmax) of ciprofloxacin were observed in six out of seven patients. The result suggests that the influence of fever on the pharmacodynamics of ciprofloxacin is favorable.

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