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. 1999 Feb;62(2):345-7.
doi: 10.1021/np980356c.

Maprouneacin, a new daphnane diterpenoid with potent antihyperglycemic activity from Maprounea africana

J R Carney  1 , J M Krenisky, R T Williamson, J Luo, T J Carlson, V L Hsu, J L Moswa
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Maprouneacin, a new daphnane diterpenoid with potent antihyperglycemic activity from Maprounea africana

J R Carney et al. J Nat Prod. 1999 Feb.

Abstract

Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Compound 2 showed potent glucose-lowering properties when given by the oral route.

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