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Review
. 1999 Apr 1;27(7):1569-77.
doi: 10.1093/nar/27.7.1569.

Towards mixed sequence recognition by triple helix formation

D M Gowers  1 , K R Fox
Affiliations
Review

Towards mixed sequence recognition by triple helix formation

D M Gowers et al. Nucleic Acids Res. .

Abstract

The formation of intermolecular DNA triple helices offers the possibility of designing compounds with extensive sequence recognition properties which may be useful as antigene agents or tools in molecular biology. One major limitation of this approach is that these structures are generally restricted to homo-purine. homopyrimidine target sites. This review describes the strategies that have been employed to overcome this drawback and outlines the potential for triplex formation at mixed sequence DNA targets.

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