doi: 10.1073/pnas.75.9.4509.
Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus
- PMID: 100786
- PMCID: PMC336145
- DOI: 10.1073/pnas.75.9.4509
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Somatostatin inhibits release of thyrotropin releasing factor from organ cultures of rat hypothalamus
Proc Natl Acad Sci U S A.
1978 Sep.
Abstract
Somatostatin in concentrations of 10(-6) to 10(-8) M inhibited basal release of thyrotropin releasing factor in organ culture of rat hypothalamus. Norepinephrine in doses of 10(-4)--10(-6) M induced release of thyrotropin releasing factor which increased progressively with time and was temperature and dose dependent. This enhanced thyrotropin-releasing-factor release was inhibited by somatostatin at 10(-6)--10(-8) M.
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