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. 1999 Feb;41(2):247-52.
doi: 10.1002/(sici)1522-2594(199902)41:2<247::aid-mrm6>3.0.co;2-u.

Investigation of the early response to rat forepaw stimulation

J J Marota  1 , C Ayata, M A Moskowitz, R M Weisskoff, B R Rosen, J B Mandeville
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Free article

Investigation of the early response to rat forepaw stimulation

J J Marota et al. Magn Reson Med. 1999 Feb.
Free article

Abstract

The role of relative cerebral blood volume (rCBV) in the early response of blood oxygenation level-dependent (BOLD) signal following sensory stimulation was assessed. Magnetic resonance imaging (MRI) measurements of rCBV and BOLD signal as a function of time (t) were compared with relative cerebral blood flow (rCBF) obtained by laser doppler flowmetry during a repeated epoch of rat forepaw stimulation in which 6 sec of electrical stimulation followed 54 sec of rest. rCBF(t) exceeded rCBV(t) in somatosensory cortex at all time points and reached a maximal increase (60%) during a 6 sec stimulation that was much higher than maximal rCBV (10%). An initial dip was not observed in BOLD signal, which showed a delay with respect to rCBF that was roughly consistent with the cerebral blood transit time.

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