doi: 10.1002/ajh.2830010402.
Inhibition of murine granulopoiesis in vitro by dexamethasone
- PMID: 1008053
- DOI: 10.1002/ajh.2830010402
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Inhibition of murine granulopoiesis in vitro by dexamethasone
Am J Hematol.
1976.
Abstract
The effect of dexamethasone on mouse bone marrow granulocyte-monocyte precursor cells (CFU-C) was studied in vitro. Dexamethasone inhibited colony formation in the presence of maximally stimulating concentrations of colony-stimulating activity. A mean colony reduction of 55% occurred at 10(-9) M dexamethasone and inhibition was observed at concentrations as low as 10(-12)M. The dexamethasone suppression could be abrogated by progesterone. These studies provide evidence that the committed granulocyte-monocyte stem cell has a glucocorticoid receptor mechanism that when activated results in inhibition of cellular proliferation in vitro.
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