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Comparative Study
. 1999 Apr;67(4):2010-2.
doi: 10.1128/IAI.67.4.2010-2012.1999.

Vaccinated mice remain more susceptible to Mycobacterium tuberculosis infection initiated via the respiratory route than via the intravenous route

R J North  1 , R LaCourse, L Ryan
Affiliations
Comparative Study

Vaccinated mice remain more susceptible to Mycobacterium tuberculosis infection initiated via the respiratory route than via the intravenous route

R J North et al. Infect Immun. 1999 Apr.

Abstract

Mice given Mycobacterium tuberculosis bacilli via the respiratory route succumbed much sooner to infection than mice given 1,000 times more bacilli via the intravenous route. Vaccination provided increased protection to an M. tuberculosis challenge infection; however, mice infected via the respiratory route remained much more susceptible.

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Figures

FIG. 1
FIG. 1
Course of M. tuberculosis infection in the lungs, livers, and spleens of BCG-vaccinated (IMM) and unvaccinated (CONT) mice infected with 8 × 102 CFU of M. tuberculosis Erdman by aerosol or with 5 × 105 CFU of M. tuberculosis Erdman i.v. Results are given as means ± standard errors (error bars) for five mice per group per time point.
FIG. 2
FIG. 2
Survival times of 10 BCG-vaccinated (IMM) and 10 unvaccinated (CONT) mice infected with 8 × 102 CFU of M. tuberculosis Erdman by aerosol or with 5 × 105 CFU of M. tuberculosis Erdman i.v.
FIG. 3
FIG. 3
Photographs of 20-μm-thick, crystal violet-stained sections of the left lung lobes of nonvaccinated (a and b) and vaccinated (c and d) mice infected with M. tuberculosis by aerosol (8 × 102 CFU) (a and c) or i.v. (5 × 105 CFU) (b and d), as described for Fig. 1 and 2. The darkly stained areas represent the most densely consolidated areas of lung tissue. There was more consolidation in nonvaccinated mice infected by aerosol. Vaccination served to reduce the rate of development of lung consolidation. Magnification, ×4.2.
See this image and copyright information in PMC

References

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