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. 1998 Jul;3(3):232-242.

Modulation of Anger and Aggression

K Anderson  1 , JM Silver
Affiliations
  • PMID: 10085211

Modulation of Anger and Aggression

K Anderson et al. Semin Clin Neuropsychiatry. 1998 Jul.

Abstract

Traumatic brain injury commonly results in anger and aggressive behavior. The hypothalamus, limbic system, and prefrontal cortex mediate aggression, and frequently are injured during trauma. Many neurotransmitters that modulate aggressive behavior, including norepinephrine, serotonin, dopamine, and acetylcholine are affected by brain injury. The pharmacological treatment of aggression is divided into medications used for acute behavioral control, and those used for the prophylaxis of episodes. Specific recommendations are made for the choice of specific medications.

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