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Review
. 1999 Mar 8;144(5):809-11.
doi: 10.1083/jcb.144.5.809.

Formin' the connection between microtubules and the cell cortex

R A Heil-Chapdelaine  1 , N R Adames, J A Cooper
Affiliations
Review

Formin' the connection between microtubules and the cell cortex

R A Heil-Chapdelaine et al. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Steps in mitotic spindle position and movement. First, the nucleus (blue) moves to nascent bud, which requires Kip3p and presumably the attachment of astral microtubules (green) to a site in the cortex of the bud (red). The attachment is transient, not permanent. Kar9p, Bni1p, filamentous actin, and Bud6p function in the movement, presumably because they are necessary for the attachment. These proteins also function in the second step, aligning the pre-anaphase spindle along the mother-bud axis. Third, concurrent with anaphase initiation, the spindle is pulled into the neck. This movement requires dynein and a presumed cortical attachment site that in some respects appears different from the one used in steps 1 and 2.
See this image and copyright information in PMC

References

    1. Amberg DC, Zahner JE, Mulholland JW, Pringle JR, Botstein D. Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites. Mol Biol Cell. 1997;8:729–753. - PMC - PubMed
    1. Cottingham FR, Hoyt MA. Mitotic spindle positioning in Saccharomyces cerevisiaeis accomplished by antagonistically acting microtubule motor proteins. J Cell Biol. 1997;138:1041–1053. - PMC - PubMed
    1. DeZwaan TM, Ellingson E, Pellman D, Roof DM. Kinesin-related Kip3 of Saccharomyces cerevisiaeis required for a distinct step in nuclear migration. J Cell Biol. 1997;138:1023–1040. - PMC - PubMed
    1. Evangelista M, Blundell K, Longtine MS, Chow CJ, Adames N, Pringle J, Peter M, Boone C. Bni1p, a yeast formin linking Cdc42p and the actin cytoskeleton during polarized morphogenesis. Science. 1997;276:118–122. - PubMed
    1. Frazier JA, Field CM. Actin cytoskeleton: are FH proteins local organizers? . Curr Biol. 1997;7:R414–R417. - PubMed

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