Review
doi: 10.1159/000014567.
Melatonin as a time-meaningful signal in circadian organization of immune response
Affiliations
- PMID: 10085461
- DOI: 10.1159/000014567
Item in Clipboard
Review
Melatonin as a time-meaningful signal in circadian organization of immune response
Biol Signals Recept.
1999 Jan-Apr.
Abstract
Melatonin is synthesized and secreted during the dark period of the light/dark cycle. The rhythmic nocturnal melatonin secretion is directly generated by the circadian clock, located within the suprachiasmatic nuclei in mammals and is entrained to a 24-hour period by the light-dark cycle. The periodic secretion of melatonin may be used as a circadian mediator to any system that can 'read' the message. Melatonin seems to act as an arm of the circadian clock, giving a time-related signal to a number of body functions; one of these, the circadian organization of the defense of the organism, is discussed in some detail as an example.
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