[Ultrastructural investigations on the pathogenesis of hyperplasias and tumors of skin connective tissue (author's transl)]

Abstract

Results of an ultrastructural investigation of 4 tumors resp. hyperplasias of skin (endometriom, lymphadenosis cutis benigna Bäfverstedt, mastozytom, oral papillomatosis) show that the substance of granules from mastcells and eosinophilic granulocytes influence the composition and synthesis of the groundsubstance and its fibrous materials. Synthesis of the groundsubstance by fibrocyte like cells can be affected by intracytoplasmic uptake of the granules or by liberated granules which can change the composition of the groundsubstance. Fibrocyte like cells can take up the granules direct from the groundsubstance and (or) possibly by intercytoplasmic bridges ("Fursome"). Composition and synthesis of groundsubstance and fibrous elements are related by a feedback system. Therefore an irregular composed groundsubstance cause an irregular synthesis by fibrocyte like cells and vice versa. From that a circulus vitiosus arise that, by our opinion, may contribute to the development of tumors, resp. hyperplasias of skin with essential participation of the connective tissue.