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. 1999 Mar;5(3):286-91.
doi: 10.1038/6502.

Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells

A K Perl  1 , U Dahl, P Wilgenbus, H Cremer, H Semb, G Christofori
Affiliations

Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells

A K Perl et al. Nat Med. 1999 Mar.

Abstract

As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient RiplTag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells.

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