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. 1999 Mar;94(3):744-50.
doi: 10.1111/j.1572-0241.1999.00946.x.

Lectin binding to human colonocytes is predictive of colonic neoplasia

D J Desilets  1 , K E Davis, P P Nair, K F Salata, C L Maydonovitch, R S Howard, J W Kikendall, R K Wong
Affiliations

Lectin binding to human colonocytes is predictive of colonic neoplasia

D J Desilets et al. Am J Gastroenterol. 1999 Mar.

Abstract

Objective: The aim of this study was to determine whether lectin binding to exfoliated human colonocytes could be used as a noninvasive test for colorectal polyps or cancer.

Methods: Colonocytes were harvested from 31 patients (10 controls, 10 with adenomatous polyps, and 11 with cancer), incubated with a panel of fluorescent-labeled lectins, and assayed by flow cytometry.

Results: The lectins jacalin (JAC) and wheat germ agglutinin (WGA) were useful in predicting the presence of a colorectal neoplasm (p = 0.0018 for JAC and p = 0.0099 for WGA). For JAC, sensitivity reached 81% with a specificity of 80%, and for WGA the sensitivity and specificity were both 75%.

Conclusions: Lectin binding to human colonocytes can predict the presence of malignant and premalignant lesions of the colon, and has potential as a noninvasive screening tool for colorectal neoplasms.

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