Review
doi: 10.1016/s0968-0004(98)01340-1.
Dealing with energy demand: the AMP-activated protein kinase
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- PMID: 10087918
- DOI: 10.1016/s0968-0004(98)01340-1
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Review
Dealing with energy demand: the AMP-activated protein kinase
Trends Biochem Sci.
1999 Jan.
Abstract
The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.
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