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Review
. 1999 Jan;24(1):22-5.
doi: 10.1016/s0968-0004(98)01340-1.

Dealing with energy demand: the AMP-activated protein kinase

B E Kemp  1 , K I Mitchelhill, D Stapleton, B J Michell, Z P Chen, L A Witters
Affiliations
Review

Dealing with energy demand: the AMP-activated protein kinase

B E Kemp et al. Trends Biochem Sci. 1999 Jan.

Abstract

The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.

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