Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1999 Jan;22(1):70-5.
doi: 10.1007/BF03345482.

Progression of a Nelson's adenoma to pituitary carcinoma; a case report and review of the literature

S A Kemink  1 , P Wesseling, G F Pieters, A A Verhofstad, A R Hermus, A G Smals
Affiliations
Review

Progression of a Nelson's adenoma to pituitary carcinoma; a case report and review of the literature

S A Kemink et al. J Endocrinol Invest. 1999 Jan.

Erratum in

  • J Endocrinol Invest 1999 Jul-Aug;22(7):582

Abstract

A 25-year-old woman developed Nelson's syndrome, 3 years after successful bilateral adrenalectomy for Cushing's disease. Despite pituitary surgery and radiotherapy the tumour showed invasive growth, leading to visual disturbance, paresis of the oculomotor nerve and, 34 years after adrenalectomy, to death by widespread purulent leptomeningitis. Autopsy revealed a large adenohypophyseal carcinoma with a metastasis attached to the dura, both tumours showing immunocytochemical staining for ACTH and TSH. We review the literature on metastatic adenohypophyseal carcinoma in Cushing's disease and Nelson's syndrome and discuss the role of proliferation markers as indicators of malignant progression.

PubMed Disclaimer

References

    1. Horm Res. 1996;46(6):257-62 - PubMed
    1. Rev Med Interne. 1991 May-Jun;12(3):209-12 - PubMed
    1. Endocr Pathol. 1995 Spring;6(1):45-55 - PubMed
    1. Neurosurgery. 1996 Apr;38(4):765-70; discussion 770-1 - PubMed
    1. Eur J Clin Invest. 1995 Feb;25(2):128-31 - PubMed

LinkOut - more resources