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Case Reports
. 1999 Mar;97(3):311-6.
doi: 10.1007/s004010050990.

Intrasellar malignant lymphoma developing within pituitary adenoma

D Kuhn  1 , M Buchfelder, T Brabletz, W Paulus
Affiliations
Case Reports

Intrasellar malignant lymphoma developing within pituitary adenoma

D Kuhn et al. Acta Neuropathol. 1999 Mar.

Abstract

A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogenetic pathways for intra-adenomatous lymphoma development include monoclonal expansion of T cell infiltrates, expression of adhesion molecules specific for adenoma endothelium, and production of mitogenic pituitary hormones.

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