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. 1999 Apr;64(4):1177-85.
doi: 10.1086/302334.

A note on power approximations for the transmission/disequilibrium test

M Knapp  1
Affiliations

A note on power approximations for the transmission/disequilibrium test

M Knapp. Am J Hum Genet. 1999 Apr.

Abstract

The transmission/disequilibrium test (TDT) is a popular method for detection of the genetic basis of a disease. Investigators planning such studies require computation of sample size and power, allowing for a general genetic model. Here, a rigorous method is presented for obtaining the power approximations of the TDT for samples consisting of families with either a single affected child or affected sib pairs. Power calculations based on simulation show that these approximations are quite precise. By this method, it is also shown that a previously published power approximation of the TDT is erroneous.

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