Repairing great duodenal defects in rabbits by ePTFE patch

Abstract

The aim of this experimental study was to evaluate the results of repairing large duodenal defects in rabbits by an ePTFE (Gore-Tex) soft tissue patch graft. A defect as large as 50% of the total circumference of the duodenum (i.e. Grade 3 injury) on anterior surface of the second part in 14 white New Zealand rabbits was done and repaired by 1 mm ePTFE graft. The stomach and duodenum were inspected for evidence of either leak or obstruction, and completeness of the mucosa covering the defect. Neither leak nor obstruction were observed and the whole grafted area was covered by the mucosa at the end of the sixth month. The main conclusion is that the method we used, is easy and reliable. Further experience will appropriate animal models is needed before this technique can be considered for application (in human duodenal injuries).