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. 1999 Mar;9(1):67-79.
doi: 10.1081/BIP-100101000.

Use of predictive probabilities in phase II and phase III clinical trials

D Johns  1 , J S Andersen
Affiliations

Use of predictive probabilities in phase II and phase III clinical trials

D Johns et al. J Biopharm Stat. 1999 Mar.

Abstract

Predictive probability is particularly useful in aiding a decision-making process related to drug development. This is especially true for decisions occurring as the result of interim analyses of clinical trials. Examples of clinical trial applications of Bayesian predictive probability and the use of the beta-binomial distribution are described.

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