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. 1999 Mar 26;283(5410):2080-2.
doi: 10.1126/science.283.5410.2080.

Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

C B Brown  1 , A S Boyer, R B Runyan, J V Barnett
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Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart

C B Brown et al. Science. .

Abstract

Transforming growth factor-beta (TGF-beta) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-beta signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-beta2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-beta signaling.

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