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. 1999 Apr 1;20(4):334-6.
doi: 10.1097/00042560-199904010-00002.

Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24

R Bristow  1 , J Byrne, J Squirell, H Trencher, T Carter, B Rodgers, E Saman, J Duncan
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Human cyclophilin has a significantly higher affinity for HIV-1 recombinant p55 than p24

R Bristow et al. J Acquir Immune Defic Syndr Hum Retrovirol. .

Abstract

The ability of cyclophilin to bind a panel of recombinant HIV-gag proteins was assessed using sensitive, quantitative, sandwich enzyme-linked immunosorbant assays (ELISAs). Significantly higher binding to cyclophilin was observed when recombinants contained at least 12 carboxy-terminal amino acids of p17 in addition to p24 sequences. These results indicate that the carboxy-terminus of p17 is important for optimal binding of cyclophilin to p24 and support the theory that cyclophilin acts on the uncleaved HIV-1 gag (p17-p24) precursor.

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