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Review
. 1999 Mar;62(3):504-40.
doi: 10.1021/np980406d.

Annonaceous acetogenins: recent progress

F Q Alali  1 , X X Liu, J L McLaughlin
Affiliations
Review

Annonaceous acetogenins: recent progress

F Q Alali et al. J Nat Prod. 1999 Mar.

Abstract

The Annonaceous acetogenins are promising new antitumor and pesticidal agents that are found only in the plant family Annonaceae. Chemically, they are derivatives of long-chain fatty acids. Biologically, they exhibit their potent bioactivities through depletion of ATP levels via inhibiting complex I of mitochondria and inhibiting the NADH oxidase of plasma membranes of tumor cells. Thus, they thwart ATP-driven resistance mechanisms. This review presents the progress made in the chemistry, biology, and development of these compounds since December 1995.

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