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Review
. 1999 Jan;17(1):35-42.
doi: 10.1016/s0167-7799(98)01248-7.

Genetic optimization of recombinant glycoprotein production by mammalian cells

M Fussenegger  1 , J E Bailey, H Hauser, P P Mueller
Affiliations
Review

Genetic optimization of recombinant glycoprotein production by mammalian cells

M Fussenegger et al. Trends Biotechnol. 1999 Jan.

Abstract

Genetically modified mammalian cells are the preferred system for the production of recombinant therapeutic glycoproteins. Other applications include engineering of cell lines for drug screening and cell-based therapies, and the construction of recombinant viruses for gene therapy. This article highlights contemporary core genetic technologies and emerging strategies for genetically engineering mammalian cells for optimal recombinant-protein expression.

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