Review
doi: 10.1016/s0167-5699(98)01391-7.
Multiple gamma c-dependent cytokines regulate T-cell development
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- PMID: 10098325
- DOI: 10.1016/s0167-5699(98)01391-7
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Review
Multiple gamma c-dependent cytokines regulate T-cell development
Immunol Today.
1999 Feb.
Free article
Abstract
Mutations in the common gamma chain (gamma c) of cytokine receptors account for human X-linked severe combined immunodeficiency disease. gamma c contributes to ligand binding and signaling as a component of five cytokine receptors: interleukin-2-receptor (IL-2R), IL-4R, IL-7R, IL-9R and IL-15R. Here, Thomas Malek and colleagues discuss the contribution of individual gamma c-dependent cytokines in both conventional and intraepithelial T-cell development.
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