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Review
. 1999 Feb;20(2):89-94.
doi: 10.1016/s0167-5699(98)01396-6.

Chemokine receptors and HIV-1: the fusion of two major research fields

R Horuk  1
Affiliations
Review

Chemokine receptors and HIV-1: the fusion of two major research fields

R Horuk. Immunol Today. 1999 Feb.

Abstract

Chemokines mediate their effects by binding to cell-surface receptors that belong to the seven-transmembrane-domain superfamily of proteins. Chemokine receptors have been subject to intense scrutiny following the recent discovery that several of them are co-receptors for HIV-1. Here, Richard Horuk reviews the latest developments in chemokine receptor research with a particular focus on their role as HIV-1 co-receptors.

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