Review
doi: 10.1016/s0968-0004(98)01343-7.
The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
Affiliations
- PMID: 10098402
- DOI: 10.1016/s0968-0004(98)01343-7
Item in Clipboard
Review
The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene
Trends Biochem Sci.
1999 Feb.
Abstract
E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.
Similar articles
-
Invasion promoter versus invasion suppressor molecules: the paradigm of E-cadherin.Mol Biol Rep. 1994 Jan;19(1):45-67. doi: 10.1007/BF00987321. Mol Biol Rep. 1994. PMID: 8170467 Review. No abstract available.
-
The role of E-cadherin and scatter factor in tumor invasion and cell motility.EXS. 1991;59:109-26. doi: 10.1007/978-3-0348-7494-6_8. EXS. 1991. PMID: 1833225 Review.
-
Inactivation of the E-cadherin-mediated cell adhesion system in human cancers.Am J Pathol. 1998 Aug;153(2):333-9. doi: 10.1016/S0002-9440(10)65575-7. Am J Pathol. 1998. PMID: 9708792 Free PMC article. Review.
-
Molecular aspects of adhesion-epigenetic mechanisms for inactivation of the E-Cadherin-mediated cell adhesion system in cancers.Verh Dtsch Ges Pathol. 2000;84:28-32. Verh Dtsch Ges Pathol. 2000. PMID: 11217445 Review.
-
N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling.Int J Dev Biol. 2004;48(5-6):463-76. doi: 10.1387/ijdb.041793ld. Int J Dev Biol. 2004. PMID: 15349821 Review.
Cited by
-
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.J Biol Chem. 2012 Jul 20;287(30):25292-302. doi: 10.1074/jbc.M111.291195. Epub 2012 May 30. J Biol Chem. 2012. PMID: 22648416 Free PMC article.
-
miR-203 regulates cell proliferation through its influence on Hakai expression.PLoS One. 2012;7(12):e52568. doi: 10.1371/journal.pone.0052568. Epub 2012 Dec 20. PLoS One. 2012. PMID: 23285092 Free PMC article.
-
Effect of disrupting cell contact on the nuclear accumulation of beta-catenin and subsequent apoptosis of rat ovarian surface epithelial cells in vitro.Endocrine. 2000 Jun;12(3):295-302. doi: 10.1385/ENDO:12:3:295. Endocrine. 2000. PMID: 10963051
-
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.Mol Cell Biol. 2004 Jan;24(1):306-19. doi: 10.1128/MCB.24.1.306-319.2004. Mol Cell Biol. 2004. PMID: 14673164 Free PMC article.
-
Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting.Int J Mol Sci. 2023 Jul 21;24(14):11745. doi: 10.3390/ijms241411745. Int J Mol Sci. 2023. PMID: 37511503 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
