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Review
. 1999 Feb;24(2):73-6.
doi: 10.1016/s0968-0004(98)01343-7.

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

G Christofori  1 , H Semb
Affiliations
Review

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene

G Christofori et al. Trends Biochem Sci. 1999 Feb.

Abstract

E-cadherin-mediated cell-cell adhesion is lost during the development of most epithelial cancers. Recent evidence indicates that the loss of E-cadherin function, besides causing loss of cell-cell adhesion, might also convey signals that actively induce tumour-cell invasion and metastasis.

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